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NFL AI Game Projections
See what AI has to say about this weeks NFL games. These AI-powered projections deliver real-time predictions on game outcomes, team performance, and key matchups. Use these data-driven insights to make smarter picks in your pick'em leagues. Stay ahead of the game with analysis powered by the latest in artificial intelligence models.AI Projections for Week 5
San Francisco 49ers @ Los Angeles Rams
PROJECTION:
Los Angeles Rams
to win by 7
AI ANALYSIS:
San Francisco's injury issues are catching up with them. The 49ers have scored six touchdowns on 14 red zone trips this season -- a 42.9% conversion rate that is tied for fifth worst in the NFL. Without George Kittle, Brandon Aiyuk, and Jauan Jennings at full strength, their red zone efficiency becomes even more problematic. The Rams showed impressive resilience coming back against Indianapolis, and Matthew Stafford at 37 continues to look like an MVP candidate. This divisional matchup favors the home team with the healthier roster.
PROJECTED SCORE:
Los Angeles Rams
27,
San Francisco 49ers
20
Minnesota Vikings @ Cleveland Browns
PROJECTION:
Minnesota Vikings
to win by 7
AI ANALYSIS:
Cleveland is making a quarterback change, benching Joe Flacco for rookie Dillon Gabriel. Minnesota comes off an impressive defensive performance in Dublin despite the loss, and they should be more comfortable with international travel behind them now. The Vikings' defense should dominate a Browns offense breaking in a new signal-caller, even if their own offense remains inconsistent with Carson Wentz.
PROJECTED SCORE:
Minnesota Vikings
20,
Cleveland Browns
13
Las Vegas Raiders @ Indianapolis Colts
PROJECTION:
Indianapolis Colts
to win by 14
AI ANALYSIS:
Indianapolis suffered a tough loss to the Rams but showed they can move the ball effectively. Daniel Jones and this Colts offense have been surprisingly potent. Las Vegas has been inconsistent and their offensive line struggles will be exposed by Indianapolis's improving pass rush. The Colts should easily bounce back in this game.
PROJECTED SCORE:
Indianapolis Colts
31,
Las Vegas Raiders
17
New York Giants @ New Orleans Saints
PROJECTION:
New Orleans Saints
to win by 3
AI ANALYSIS:
Jaxson Dart's debut win was impressive, but the loss of Malik Nabers for the season fundamentally changes New York's offense. the Giants also lost their best offensive player in losing Malik Nabers for the season. New York had just 89 team passing yards on Sunday. New Orleans desperately needs a win and playing at home in the Superdome should provide the spark they need against a Giants team with major offensive limitations.
PROJECTED SCORE:
New Orleans Saints
20,
New York Giants
17
Dallas Cowboys @ New York Jets
PROJECTION:
Dallas Cowboys
to win by 4
AI ANALYSIS:
Both teams desperate for a win after disappointing starts. After Week 4 of the 2025 NFL season, the Bills and Eagles are the only undefeated teams left in the league. On the other end, the Titans, Saints and Jets are all 0-4. The Jets' winless start under Aaron Glenn puts enormous pressure on this game. Dallas, even coming off the bizarre tie with Green Bay, has more offensive firepower and should edge a Jets team still searching for their identity.
PROJECTED SCORE:
Dallas Cowboys
24,
New York Jets
20
Denver Broncos @ Philadelphia Eagles
PROJECTION:
Philadelphia Eagles
to win by 10
AI ANALYSIS:
Philadelphia remains undefeated and faces a Denver team that struggled with penalties despite beating Cincinnati. Currently, Denver's offense is tied as the fourth-most penalized offense. Center Luke Wattenberg has been flagged six times in 2025, including four penalties on Monday night. The Eagles' defensive opportunism should capitalize on Denver's self-inflicted wounds. Bo Nix will face his toughest test yet against a championship-caliber defense.
PROJECTED SCORE:
Philadelphia Eagles
27,
Denver Broncos
17
Miami Dolphins @ Carolina Panthers
PROJECTION:
Miami Dolphins
to win by 6
AI ANALYSIS:
Miami finally got their first win over the Jets and should build momentum. Tyreek Hill's knee injury is concerning, but even without him the Dolphins have enough weapons. Carolina continues to struggle generating pressure, and their offensive inconsistency makes them vulnerable against a Miami defense that finally found some rhythm.
PROJECTED SCORE:
Miami Dolphins
23,
Carolina Panthers
17
Houston Texans @ Baltimore Ravens
PROJECTION:
Baltimore Ravens
to win by 7
AI ANALYSIS:
Houston's 0-3 start has been misleading as they've competed in close games, but Baltimore presents a different challenge entirely. The Ravens need to bounce back after getting dominated by Kansas City, and playing at home provides a good opportunity. Lamar Jackson should have a field day against a Texans secondary that has been vulnerable.
PROJECTED SCORE:
Baltimore Ravens
28,
Houston Texans
21
Tennessee Titans @ Arizona Cardinals
PROJECTION:
Arizona Cardinals
to win by 17
AI ANALYSIS:
This spread feels justified. Tennessee looks completely lost on both sides of the ball, and Arizona should dominate at home despite losing James Conner. The Cardinals have enough offensive weapons to overwhelm a Titans defense that has given up big plays consistently. Rookie Cam Ward will face pressure all day from Arizona's front seven.
PROJECTED SCORE:
Arizona Cardinals
27,
Tennessee Titans
10
Tampa Bay Buccaneers @ Seattle Seahawks
PROJECTION:
Seattle Seahawks
to win by 3
AI ANALYSIS:
Seattle's 3-1 start has been impressive, and their home field advantage at Lumen Field remains significant. Tampa Bay lost a heartbreaker to the undefeated Eagles and now faces a cross-country trip. Mike Evans being out multiple weeks hurts their offensive rhythm. The Seahawks' defensive improvements should contain Tampa Bay's passing attack enough to secure a close victory.
PROJECTED SCORE:
Seattle Seahawks
24,
Tampa Bay Buccaneers
21
Detroit Lions @ Cincinnati Bengals
PROJECTION:
Detroit Lions
to win by 14
AI ANALYSIS:
Detroit continues rolling, and Cincinnati without Joe Burrow looks overwhelmed. Jake Browning has thrown five interceptions already, and facing a Lions defense that has found its groove spells trouble. This spread might not be enough - the Lions' offensive weapons should have a field day against a Bengals defense missing key pieces.
PROJECTED SCORE:
Detroit Lions
34,
Cincinnati Bengals
20
Washington Commanders @ Los Angeles Chargers
PROJECTION:
Los Angeles Chargers
to win by 3
AI ANALYSIS:
Los Angeles needs to rebound after Jaxson Dart's debut stunned them. Sunday was a continuation of the norm for these Chargers, who have struggled to protect Justin Herbert all season. The Giants recorded a pass rush win rate of 68% against the Chargers. Despite their offensive line issues, the Chargers have too much talent to lose a home game against the Commanders. Washington's defense will make it competitive, but Herbert will find a way.
PROJECTED SCORE:
Los Angeles Chargers
26,
Washington Commanders
23
New England Patriots @ Buffalo Bills
PROJECTION:
Buffalo Bills
to win by 14
AI ANALYSIS:
Buffalo remains undefeated and looks like the best team in football. New England's dominant win over Carolina was encouraging, but facing Josh Allen in primetime at Highmark Stadium is a different challenge entirely. The Bills' defense will pressure Drake Maye into mistakes, and their offense has too many weapons for a Patriots secondary still finding its identity.
PROJECTED SCORE:
Buffalo Bills
31,
New England Patriots
17
Kansas City Chiefs @ Jacksonville Jaguars
PROJECTION:
Kansas City Chiefs
to win by 4
AI ANALYSIS:
Kansas City finally looked like themselves in dismantling Baltimore, and Patrick Mahomes threw four touchdowns for the first time since 2023. The Jaguars pulled off an impressive upset over the 49ers but face a completely different animal here. The Jaguars lead the NFL in called (30) and accepted (23) offensive penalties. That includes 10 holding penalties, second most in the league. Jacksonville's penalty problems will hurt them in a tight game, and the Chiefs' experience in these situations gives them the edge.
PROJECTED SCORE:
Kansas City Chiefs
28,
Jacksonville Jaguars
24